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. 2018 Nov 5;215(11):2887–2900. doi: 10.1084/jem.20172021

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© 2018 Malhotra et al.

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Figure 1. — iNKT cell development is severely impaired in mice lacking Sox4 in hematopoietic cells. (A) Representative flow cytometric analyses show decreased frequencies of iNKT cells in the thymus, spleen, peripheral LNs, liver, and lung of WT (Cd2-iCre; Sox4^+/+) and Cd2-iCre;Sox4^fl/fl CKO mice. One of three independent experiments (minimum of three mice per genotype) is shown. (B) Summary of frequencies and cell numbers of iNKT cells in the thymus and spleen, with statistical significance denoted (***, P < 0.001, Student’s t test). Error bars denote SD. (C) γδTCR⁺ NKT cells (Vγ1.1⁺Vδ6.3⁺) as shown among gated γδTCR⁺ cells are not altered in CKO mice. Representative plots from one of two independent experiments.