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. 2018 Nov 5;215(11):2850–2867. doi: 10.1084/jem.20172026

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© 2018 Chen et al.

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Figure 3. — USP38 is crucial for HDM-induced asthma. (A–I) 6–8-wk-old female usp38^−/− mice and their littermate controls were analyzed individually. PBS group (n = 3); HDM group (n = 5). (A) A schematic diagram of HDM-induced asthma. (B) Total number of BALF cells. (C) Cell counts of eosinophils or lymphocytes in BALF determined by flow analysis. (D) Percentages and absolute numbers of the indicated T cell subpopulations in medLNs. (E) Levels of Th2 cytokines determined by ELISA from Th2 ex vivo recall response. (F) H&E staining of lung sections from PBS- or HDM-treated mice. Original magnification is 10×. Bars, 100 µm. (G) Pathological score of perivascular and peribronchiolar inflammation as shown in F. (H) PAS staining of lung sections from PBS- or HDM-treated mice. Original magnification is 10×. Bars, 100 µm. (I) Quantification of goblet cell hyperplasia as shown in H. Data are representative of four (A–C) or two (D–I) independent experiments. Statistical significance was determined by Student’s t test; *, P < 0.05; **, P < 0.01; ***, P < 0.001. Error bars indicate the mean ± SEM.