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. 2018 Nov 6;13(11):e0207031. doi: 10.1371/journal.pone.0207031

Fig 3. Developmental changes in the percentage of time, number of transitions, and bout durations of vigilance states of the neonatal mouse.

Fig 3

(A) Percentage of recorded time spent in vigilance states of P10 through P21 mice. Older mice display a significant increase in wakefulness and decrease in REM sleep compared to P10, P12, and P14 neonates. p<0.001 compared to ***P21; ###P17, p <0.01 compared to **P21; ##P17, p<0.05 compared to *P21; #P17 by one-way repeated measures ANOVA with Tukey; n = 8–9 mice per group. (B) The number of vigilance state transitions of P10 through P21 mice. The number of vigilance state transitions into sleep and the number of REM transitions decrease in the developing mouse. p<0.001 compared to ***P21; ###P17, p <0.01 compared to **P21; ◆◆P17, p<0.05, compared to *P21; #P17; ◆P14 by one-way repeated measures ANOVA; n = 8–9 mice per group. (C) The bout duration of vigilance states of P10 through P21 mice. The bout duration of wakefulness and NREM sleep increases during development. p<0.001 compared to ***P21; ###P17, p<0.05 compared to *P21; #P17 by one-way repeated measures ANOVA with Tukey; n = 8–9 mice per group.