Figure 6.

Mean arterial pressure (A), systolic blood pressure (B), diastolic blood pressure (C), pulse pressure (D) and heart rate (E) in WT and KO male (left) and female (right) rats given DOCA, salt water, and uninephrectomy at the dashed vertical lines on d 8/9. Points are means ± sem for the number of animals in parentheses. Repeated-measures 1-way ANOVA was performed, followed by Tukey’s post hoc on all 4 groups and only within-sex differences are shown in the graphs, grouped separately for clarity. Asterisk denotes statistically significant (P < 0.05) differences between WT and KO overall; dagger indicates difference as determined within week-to-week comparison for simplicity.