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. 2018 Jun 15;32(12):6822–6832. doi: 10.1096/fj.201800458

Figure 4.

Figure 4

Low-dose and 1-time high-dose losartan treatments on TEVG patency and their physiologic effects in mice. A, B) Comparison of TEVG patency between the untreated control and either low-dose losartan treatment (2–wk, 0.1 g/L) (A) or 1-time high-dose losartan (0.6 g/L) (B). C) Comparison of losartan concentration in plasma between the low-dose and high-dose losartan groups. D) Weight change comparison among the control, low-dose, and high-dose losartan groups. E) Mean arterial pressure comparison among the control, low-dose, and high-dose losartan groups. F) Cardiac output comparison among the control, low-dose, and high-dose losartan groups. Untreated control and 1-time high-dose losartan groups (n = 25); short-term low-dose losartan group (n = 8). *P < 0.05, **P < 0.01, ***P < 0.001.