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. Author manuscript; available in PMC: 2019 Nov 15.
Published in final edited form as: J Immunol. 2018 Oct 5;201(10):2910–2922. doi: 10.4049/jimmunol.1700638

Figure 7. Helminth-induced suppression of lethal GVHD and promotion of survival does not require host iNKT cells but requires IL4 generation by host cells.

Figure 7.

(A) Kaplan-Meier survival curves for Hpb-infected or uninfected iNKT-deficient (Jα18−/−) and WT BALB/c male BMT recipients that received TCD-BM cells (TCD BM) only, or TCD-BM plus total splenic T (TCD-BM + T) cells, from 5–6 week old male WT C57BL/6 donor mice. Cumulative data from multiple independent experiments that involved Jα18−/− and BALB/c WT hosts (N: cumulative number of BMT mice from multiple experiments); *p: NS between WT C57BL/6 TCD-BM + T donor cells into Hpb-infected Jα18−/− and WT C57BL/6 TCD-BM + T donor cells into Hpb-infected BALB/c WT hosts. (B) Kaplan-Meier survival curves for Hpb-infected or uninfected IL4−/− and WT BALB/c male BMT recipients of C57BL/6 WT donors; p<0.001 between TCD-BM + T donor cells into Hpb-infected IL4−/− and TCD-BM + T donor cells into Hpb-infected BALB/c WT hosts.