Table 1. Published prospective trials evaluating proton beam radiotherapy for hepatocellular carcinoma.
Study (year published) | No. patients | Child-Pugh class A (%) | Dose/fractions | Local control, 3 years (%) | Survival, 3 years (%) |
---|---|---|---|---|---|
Kawashima [2005] | 30 | 66 | 76 Gy/20 fx | 96 | 62 |
Fukumitsu [2009] | 51 | 80 | 66 Gy/10 fx | 95 | 49 |
Bush [2011] | 76 | 29 | 63 Gy/15 fx | 80* | ~24 |
Hong [2016] | 44 | 73 | 58 Gy/15 fx | 95 (2 years) | 63 (2 years) |
Bush [2016] | 33 | N.R. | 70.2 Gy/15 fx | 88 | N.R. |
*, crude rate. N.R., not reported.