Table 2. Multivariate analysis.

Variable	Non-PSM				PSM
	HR	95% CI	P		HR	95% CI	P
Age	1.01	1.00–1.01	<0.001		1.01	1.01–1.02	<0.001
Gender
Male	REF	REF	REF		REF	REF	REF
Female	0.99	0.93–1.05	0.73		0.94	0.84–1.04	0.22
Charlson/Deyo
0	REF	REF	REF		REF	REF	REF
1	1.07	1.00–1.14	0.06		1.14	1.01–1.28	0.04
2	1.11	0.97–1.25	0.12		1.35	1.03–1.77	0.03
Path T-stage
T0	REF	REF	REF		REF	REF	REF
T1	0.49	0.20–1.20	0.12		0.46	0.15–1.45	0.19
T2	0.47	0.19–1.13	0.09		0.4	0.13–1.27	0.12
T3	0.52	0.22–1.25	0.15		0.48	0.15–1.50	0.21
T4	0.71	0.28–1.76	0.45		0.55	0.16–1.85	0.33
Path N-stage
N0	REF	REF	REF		REF	REF	REF
N1	1.59	1.50–1.69	<0.001		1.48	1.31–1.68	<0.001
Grade
Low	REF	REF	REF		REF	REF	REF
Intermediate	1.22	1.09–1.37	0.001		1.25	1.03–1.51	0.02
High	1.58	1.41–1.77	<0.001		1.76	1.44–2.13	<0.001
Tumor size
≤2 cm	REF	REF	REF		REF	REF	REF
>2 cm	1.35	1.22–1.49	<0.001		1.45	1.28–1.64	<0.001
Surgical margins
R0	REF	REF	REF		REF	REF	REF
R1/R2	1.39	1.30–1.50	<0.001		1.54	1.35–1.75	<0.001
Facility volume
Low (<10/yr)	REF	REF	REF		REF	REF	REF
Med (11–19/yr)	0.96	0.89–1.03	0.22		1.02	0.91–1.16	0.7
High (>20/yr)	0.92	0.85–0.99	0.03		0.91	0.79–1.06	0.22
Treatment
Def surgery, adjv	REF	REF	REF		REF	REF	REF
Neo chemo	0.92	0.80–1.06	0.27		0.69	0.49–0.99	0.04
Neo chemo/rad	1.1	0.98–1.25	0.12		1.35	1.09–1.67	0.006