Table 1.

Biologic molecules in platelet-rich plasma [11, 12]

Molecule	Source	Function
PDGF	Platelets, macrophages	Chondrocyte chemotaxis, MSC proliferation, angiogenesis, chondrogenesis
VEGF	Platelets, macrophages, neutrophils	Angiogenesis, endothelial migration
TGF-β	Platelets, macrophages	MSC and fibroblast proliferation, production of collagen, re-epithelialization
EGF	Platelets, macrophages, plasma	Re-epithelialization, organization of granulation tissue
FGF	Platelets	Endothelial proliferation, angiogenesis, collagen production
IGF	Plasma	Cell proliferation, production of proteoglycan, collagen
MMPs	Macrophage, Neutrophils	ECM turnover, tissue remodeling, and recruitment of proliferative cells

PDGF, platelet-derived growth factor; VEGF, vascular endothelial growth factor; TGF-β, transforming growth factor-β; EGF, endothelial growth factor; FGF, fibroblast growth factor; IGF, insulin-like growth factor; MMPs, matrix metalloproteinases.; ECM, extracellular matrix