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. 2018 Aug 23;26(11):521–532. doi: 10.1007/s12471-018-1148-7

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Echocardiographic deformation imaging. Longitudinal follow-up of a 51-year-old female with breast cancer with a high cardiovascular risk (Cardiotoxicity Risk Score 7: female, hypertension, concurrent anthracyclines, and high-risk agent trastuzumab). After the initial 4 × AC (adriamycin-cyclophosphamide) there was a significant decrease of >15% in global longitudinal strain (GLS) with preservation of left ventricular ejection fraction (LVEF). During the trastuzumab treatment there was a subsequent decrease in LVEF of >10%. After interruption of the trastuzumab treatment, the LVEF showed a complete recovery