Table 2.

Cardiotoxicity Risk Score (CRS)

Medication-related risk a		Examples b
High (risk score 4)		Anthracyclines; trastuzumab; cyclophosphamide; 5‑fluorouracil
Intermediate (risk score 2)		Pertuzumab; vinblastine; capecitabine; ponatinib
Low (risk score 1)		Bevacizumab; imatinib
Rare (risk score 0)		Carboplatin; fludarabine; paclitaxel; rituximab
Patient-related risk factors (1 point per item)
– Cardiomyopathy or heart failure – Coronary artery disease or equivalent (including peripheral artery disease) – Hypertension – Diabetes mellitus – Prior or concurrent anthracyclines – Prior or concurrent chest irradiation – Age <15 years or >65 years – Female gender
Overall risk by CRS and intensity of monitoring
>6 5–6 3–4 1–2 0	Very high High Intermediate Low Very low

^aThe highest medication-related risk score (e. g. 4, 2, 1 or 0) is used for calculation of the CRS

^bSee the supplementary table for each separate agent and/or regime. Adapted from: [14]