Table 3.
Ongoing clinical trials on the treatment of cardiotoxicity
| Location | NCT number | Title | Intervention | Start date | |
|---|---|---|---|---|---|
| USA | NCT02943590 | STOP-CA (Statins TO Prevent the Cardiotoxicity from Anthracyclines) | Atorvastatin or placebo | January 2017 | Recruiting |
| USA | NCT02674204 | STOP Heart Disease in Breast Cancer Survivors Trial | Atorvastatin or placebo | May 2016 | Recruiting |
| USA | NCT02096588 | Detection and Prevention of Anthracycline-Related Cardiac Toxicity with Concurrent Simvastatin | Simvastatin or placebo | May 2014 | Active, not recruiting |
| Canada | NCT03186404 | Statins for the Primary Prevention of Heart Failure in Patients Receiving Anthracycline Pilot Study | Atorvastatin or placebo | July 2017 | Not yet recruiting |
| UK | NCT03265574 | PROACT: Can We Prevent Chemotherapy-Related Heart Damage in Patients with Breast Cancer? | Enalapril or placebo | September 2017 | Not yet recruiting |
| Italy | NCT01968200 | Prevention of Anthracycline-Induced Cardiotoxicity | Enalapril | December 2012 | Active, not recruiting |
| USA | NCT02177175 | Carvedilol for the Prevention of Anthracycline/Anti-HER2 Therapy Associated Cardiotoxicity among Women with HER2-Positive Breast Cancer Using Myocardial Strain Imaging for Early Risk Stratification | Carvedilol or placebo | June 2014 | Active, not recruiting |
| Brazil | NCT01724450 | Carvedilol Effect in Preventing Chemotherapy-Induced Cardiotoxicity | Carvedilol or placebo | June 2012 | Recruiting |
| USA | NCT02717507 | Carvedilol in Preventing Heart Failure in Childhood Cancer Survivors | Carvedilol or placebo | April 2016 | Recruiting |
| USA | NCT01347970 | Pharmacologic Reversal of Ventricular Remodeling in Childhood Cancer Survivors at Risk for Congestive Heart Failure (PREVENT-CHF): A Phase IIB Randomized Placebo-Controlled Trial | Carvedilol or placebo | May 2012 | Active, not recruiting |
| Italy | NCT02236806 | Cardiotoxicity Prevention in Breast Cancer Patients Treated with Anthracyclines and/or Trastuzumab | Bisoprolol or ramipril or placebo | July 2015 | Recruiting |
| Canada | NCT01016886 | Multidisciplinary Approach to Novel Therapies in Cardiology Oncology Research | Perindopril or bisoprolol or placebo | September 2010 | Active, not recruiting |
| USA | NCT01009918 | Lisinopril or Coreg CR® in Reducing Side Effects in Women with Breast Cancer Receiving Trastuzumab | Carvedilol or lisinopril or placebo | March 2010 | Active, not recruiting |