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. 2018 Oct 31;9:1237. doi: 10.3389/fphar.2018.01237

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Copyright © 2018 Qiu, Guo, Liu, Luo, Fan, Deng, Cui, Lu, Zhang, He and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PZH ameliorated clinical symptoms of EAE mice. SJL mice were oral administered with distilled water or PZH (0.234 g/kg/d) or FTY720 (1 mg/kg/d) daily for 60 days from day 10 (disease onset) after immunization. (A) Time course changes of mean clinical score of mice from respective group. (B) The survival rate of mice in each group. (C) Number of relapse of mice in each group. Average number of relapses = the sum of the number of relapses of all mice in each group / the number of each group. (D) Length of relapses of mice in each group. Length of relapses (days) = the sum of the number of relapse days of all mice in each group / the number of each group. Results were shown as mean ± SD (n = 5 each group; ^#P < 0.05, ^##P < 0.01 when normal group vs. model group; ^*P < 0.05, ^**P < 0.01 when treatment group vs model group).