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. 2018 Oct 31;9:1237. doi: 10.3389/fphar.2018.01237

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Copyright © 2018 Qiu, Guo, Liu, Luo, Fan, Deng, Cui, Lu, Zhang, He and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PZH ameliorated CNS inflammation and reduced demyelination in EAE mice. Mice were sacrificed at day 70 p.i. and the CNS were harvested. (A) Inflammation of brain and lumbar spinal cord was analyzed by H&E staining. (B) Demyelination of lumbar spinal cord was examined by Luxol fast blue (LFB) staining. (C) Inflammation score of the brain of mice in each group. (D) Inflammation score of the lumbar cord of mice in each group. (E) Demyelination score of the lumbar cord of mice in each group. Data were shown as mean ± SD (n = 5 in each group; ^**P < 0.01).