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. 2018 Oct 31;9:2366. doi: 10.3389/fimmu.2018.02366

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Copyright © 2018 De Bruyne, Hoste, Bogaert, Van den Bossche, Tavernier, Parthoens, Migaud, Konopnicki, Yombi, Lambrecht, van Daele, Alves de Medeiros, Brochez, Beyaert, De Baere, Puel, Casanova, Goffard, Savvides, Haerynck, Staal and Dullaers.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pedigrees. CARD9 R70W mutations were identified in five families. Each kindred is identified by a number (F1–F5), each generation by a Roman numeral (I–V), and each subject by an Arabic numeral (1–12). Square, circle and diamond shapes indicate male, female, and sex unknown, respectively. A double line represents reported consanguinity. Diagonal lines indicate deceased individuals. Filled symbols represent affected individuals, clear symbols represent unaffected individuals. The index patients are indicated with arrows. Where available, the genotype is mentioned. WT, wild-type allele.