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. 2018 Oct 31;9:640. doi: 10.3389/fendo.2018.00640

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Copyright © 2018 Zhou, Zhang, Chen, Hu and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of verapamil on protein expression of NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome complex in livers of HF diet-fed mice. (A) Representative Western blots for NLRP3, ASC, Casp-1 and β-actin. Densitometric analysis of (B) NLRP3, (C) ASC, and (D) Casp-1. Protein expression of each target was normalized to that of β-actin. Similar results were obtained among three independent experiments.The result of one of the experiments is shown. (E) IL-1β and (F) IL-18 concentrations in livers. The values were presented as means ± SD (n = 10 per group, *p < 0.05). ND, normal diet; VER, verapamil; HFD, high-fat diet.