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. 2018 Nov 7;7:176. doi: 10.1038/s41426-018-0178-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Time-resolved Bayesian HA1 phylogeny and amino-acid identity at each of the 20 mAb escape residues found to significantly affect HI titres with polyclonal chicken antisera. Amino-acid identity is shown by colour, grouped by side-chain property, according to the legend. Each virus (n = 330) included in the phylogeny has associated HI data and was included in integrated modelling of genetic and antigenic data