Table 3.
Time-varying adjusted hazard ratios and absolute difference in mortality rate per 100 for patients receiving optimal care compared with suboptimal care according to low, intermediate and high GRACE risk score category after multiple imputation for missing data*
| Optimal care vs. suboptimal care |
Optimal care vs. suboptimal care |
Optimal care vs. suboptimal care |
||||
|---|---|---|---|---|---|---|
| Low GRACE risk |
Intermediate GRACE risk |
High GRACE risk |
||||
| aHRa | Difference in AMR/100 | aHRa | Difference in AMR/100 | aHRa | Difference in AMR/100 | |
| HR over total follow-up time | 0.76 (0.60–0.96) | −0.01 (−0.02 to −0.002) | 0.66 (0.56–0.77) | −0.03 (−0.04 to −0.02) | 0.55 (0.48–0.63) | −0.07 (−0.09 to −0.05) |
| Time varying HRs | ||||||
| 30 days | 0.92 (0.69–1.38) | −0.01 (−0.06 to 0.03) | 0.74 (0.62–0.92) | −0.15 (−0.23 to −0.08) | 0.66 (0.53–0.86) | −0.19 (−0.29 to −0.08) |
| 1 | 0.71 (0.47–1.49) | −0.02 (−0.04 to 0.01) | 0.85 (0.64–1.25) | −0.03 (−0.08 to 0.02) | 0.53 (0.42–0.74) | −0.18 (−0.25 to −0.12) |
| 2 | 0.71 (0.43–1.93) | −0.01 (−0.04 to 0.01) | 0.92 (0.66–1.47) | −0.01 (−0.06 to 0.04) | 0.56 (0.42–0.82) | −0.12 (−0.17 to −0.07) |
| 3 | 0.70 (0.42–2.31) | −0.01 (−0.03 to 0.01) | 0.96 (0.68–1.58) | −0.0050 (−0.05 to 0.04) | 0.58 (0.44–0.87) | −0.09 (−0.13 to −0.05) |
| 4 | 0.70 (0.41–2.66) | −0.01 (−0.03 to 0.01) | 0.98 (0.70–1.65) | −0.0017 (−0.04 to 0.04) | 0.60 (0.45–0.90) | −0.07 (−0.1 to −0.03) |
| 5 | 0.71 (0.40–2.97) | −0.01 (−0.03 to 0.01) | 1.00 (0.71–1.68) | 0.0001 (−0.03 to 0.03) | 0.62 (0.46–0.92) | −0.06 (−0.09 to −0.02) |
| 6 | 0.71 (0.40–3.25) | −0.01 (−0.03 to 0.01) | 1.02 (0.72–1.70) | 0.0012 (−0.03 to 0.03) | 0.63 (0.48–0.94) | −0.05 (−0.07 to −0.2) |
| 7 | 0.71 (0.39–3.51) | −0.01 (−0.02 to 0.01) | 1.03 (0.74–1.71) | 0.0019 (−0.03 to 0.03) | 0.64 (0.49–0.95) | −0.04 (−0.06 to −0.02) |
| 8 | 0.71 (0.39–3.74) | −0.01 (−0.02 to 0.01) | 1.04 (0.74–1.71) | 0.0023 (−0.02 to 0.03) | 0.66 (0.50–0.96) | −0.03 (−0.06 to −0.01) |
aHR, adjusted hazard ratio; AMR, absolute mortality rate; GRACE, Global registry of Acute Coronary Events, categorized into low (<109), intermediate (109 to ≤140), and high (>140) risk.
aHR—adjusted hazard ratio obtained from flexible parametric survival modelling on the odds scale with five degrees of freedom and time-varying covariates for optimal care and GRACE risk, adjusted for: patient demographics (sex, year, and Index of Multiple Deprivation) and medical history (history of diabetes, smoking status, family history of coronary heart disease, hypertension, previous myocardial infarction, previous angina, peripheral vascular disease, cerebrovascular disease, chronic obstructive pulmonary disease or asthma, chronic renal failure, congestive cardiac failure, previous percutaneous coronary intervention, previous coronary artery bypass graft surgery, and total cholesterol).
P < 0.001 for interaction.