Table 2.
Correlation between immunohistochemical expression of Flt-4, VEGF-C, CNTN-1 and clinicopathological variables
| Flt-4 | VEGF-C | CNTN-1 | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
|
|||||||||||||||
| Variable | n | Positive (n = 23) | Negative (n = 32) | P value | Positive (n = 23) | Negative (n = 32) | P value | Positive (n = 29) | Negative (n = 26) | P value | |||||||
|
|
|
|
|||||||||||||||
| n | (%) | n | (%) | n | (%) | n | (%) | n | (%) | n | (%) | ||||||
| Age | > 60 | 26 | 12 | (46.2) | 14 | (53.8) | 0.592 | 9 | (34.6) | 17 | (65.4) | 0.413 | 12 | (46.2) | 14 | (53.8) | 0.423 |
| ≤ 60 | 29 | 11 | (37.9) | 18 | (62.1) | 14 | (48.3) | 15 | (51.7) | 17 | (58.6) | 12 | (41.4) | ||||
| Sex | Men | 39 | 21 | (53.8) | 18 | (46.2) | 0.006* | 17 | (43.6) | 22 | (56.4) | 0.769 | 20 | (51.3) | 19 | (48.7) | 0.775 |
| Women | 16 | 2 | (12.5) | 14 | (87.5) | 6 | (37.5) | 10 | (69.5) | 9 | (56.3) | 7 | (43.7) | ||||
| T classification | 1 | 29 | 10 | (34.5) | 19 | (65.5) | 0.400 | 7 | (24.1) | 22 | (75.9) | 0.015* | 13 | (81.3) | 16 | (18.7) | 0.343 |
| 2 | 11 | 4 | (36.4) | 7 | (63.6) | 5 | (45.5) | 6 | (54.5) | 5 | (45.5) | 6 | (54.5) | ||||
| 3 | 11 | 6 | (54.5) | 5 | (45.5) | 8 | (72.7) | 3 | (27.3) | 8 | (72.7) | 3 | (27.3) | ||||
| 4 | 4 | 3 | (75.0) | 1 | (25.0) | 3 | (75.0) | 1 | (25.0) | 3 | (75.0) | 1 | (25.0) | ||||
| Neck metastasis | Negative | 38 | 11 | (28.9) | 27 | (71.1) | 0.007* | 10 | (26.3) | 28 | (73.7) | 0.001* | 16 | (42.1) | 22 | (57.9) | 0.022* |
| Positive | 17 | 12 | (70.6) | 5 | (29.4) | 13 | (76.5) | 4 | (23.5) | 13 | (76.5) | 4 | (23.5) | ||||
| Differentiation | Well | 44 | 21 | (47.7) | 23 | (52.3) | 0.097 | 17 | (38.6) | 27 | (61.4) | 0.496 | 21 | (47.7) | 23 | (52.3) | 0.185 |
| Moderately or poorly | 11 | 2 | (18.2) | 9 | (81.8) | 6 | (54.5) | 5 | (45.5) | 8 | (72.7) | 3 | (27.3) | ||||
| Vascular invasion | Negative | 43 | 17 | (39.5) | 26 | (60.5) | 0.530 | 15 | (34.9) | 28 | (65.1) | 0.095 | 19 | (44.2) | 24 | (55.8) | 0.022* |
| Positive | 12 | 6 | (50.0) | 6 | (50.0) | 8 | (66.7) | 4 | (33.3) | 10 | (83.3) | 2 | (16.7) | ||||
| Lymphatic invasion | Negative | 43 | 17 | (39.5) | 26 | (60.5) | 0.530 | 16 | (37.2) | 27 | (62.8) | 0.208 | 19 | (44.2) | 24 | (55.8) | 0.022* |
| Positive | 12 | 6 | (50.0) | 6 | (50.0) | 7 | (58.3) | 5 | (41.7) | 10 | (83.3) | 2 | (16.7) | ||||
*
Statistically significant according to Fisher’s exact test (two-tailed).