Table 2.

Iron metabolism genes involved in ferroptosis

Gene	Name	Function
TFRC	Transferrin receptor	Imports iron into cells; promotes ferroptosis
HSPB1	Heat shock protein beta 1	Regulates iron uptake and GPX4 abundance; promotes ferroptosis
IRP2/IREB2	Iron-regulatory protein 2	Post-transcriptionally repress ferritin expression and increase TFR1 expression; promotes ferroptosis
DMT1	Divalent metal transporter 1	Transporting ferrous iron; promotes ferroptosis
FTH1	Ferritin heavy chain 1	Store excess intercellular iron; inhibits ferroptosis
NCOA4	Nuclear receptor coactivator 4	Involved in ferritinophagy and control of free iron abundance; promotes ferroptosis
FPN	Ferroportin	mediate iron efflux; inhibits ferroptosis