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. 2018 Nov 7;9:4647. doi: 10.1038/s41467-018-06950-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — O-glycome profiles. a Representative MALDI-TOF MS spectra of permethylated OGs isolated from brain. All MS spectra are provided in Supplementary Figure 4. b Tissues-specific distribution and relative quantification of OGs according to following glycan epitopes: nature of substituting sialic acids (Neu5Ac, Neu5Gc, Kdn), core-1 Galβ1-3GalNAc, Core-2 Galβ1-3(GlcNAcβ1-6)GalNAc, Fucα1-3GalNAcβ, and oligosialylation. The nature of individual glycans was established by a combination of MS/MS, GC/MS, and NMR, in comparison with previous work^28,29. Tissue-specific distribution of glycans is presented in Supplementary Data 2. Relative quantifications of individual compounds were extracted from dataset presented in Supplementary Figure 5. c Number of OGs identified in each organ (upper panel) and proportion of sialylated OGs in each organ expressed as the percentage of OGs substituted by any of the three sialic acids (purple bars, Neu5Ac; light blue bars, Neu5Gc; green bars, Kdn); numbers indicate the overall percentage of sialylated OGs relative to total OGs in the corresponding organs. It should be noted that a single OG may bear different types of sialic acids