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. 2018 Nov 7;9:4647. doi: 10.1038/s41467-018-06950-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Glyco-lipidome profiles. a Representative MALDI-TOF MS spectra of permethylated GSLs isolated from brain. All MS spectra are provided in Supplementary Figure 6. b Tissue-specific distribution of the glycan moieties of GSLs according to following glycan epitopes: nature of substituting sialic acids (Neu5Ac, Neu5Gc, Kdn), the GSL families (Lacto; hemato and ganglio Hm + Gg; extended galglio ExGg; lacto-ganglio LnGg), Fucα1,3GalNAcβ, and oligo-fucosylation. The presence of multiple ceramides prevents reliable quantification. The identified species are depicted in red and the non-detected ones in dark-blue. c From top to bottom panels: distribution of ceramides expressed as the percentage of GSLs bearing one or the other sphingoïd base (dark red bars, d18:0; medium red bars, d18:1; light red bars, t18:0); distribution of families expressed as the percentage of GSLs from one or the other family; occurrence of fucosylation expressed as the proportion of GSLs substituted by at least one fucose residue; sialylation pattern expressed as the percentage of GSLs substituted by any of the three sialic acids (purple bar, Neu5Ac; light blue bars, Neu5Gc; green bars, Kdn); numbers indicate the overall percentage of sialylated GSLs relative to total GSLs in the corresponding organs. It should be noted that a single GSL may harbor different types of sialic acids