Table 2.
HO drug resistance genes evolve at an accelerated rate
| Mtb drug targets | ||
|---|---|---|
| Avg. dN/dS | % dN/dS > 1 | |
| CD | 0.81 ± 0.16 | 20% |
| HO | 1.21 ± 0.21 | 50% |
The mutation rates of core gene drug targets in multi, extensively, or totally drug-resistant Mtb strains were analyzed by gene orientation. Genes under overt positive selection are indicated as the fraction of genes with a dN/dS value >1. Drug targets were previously compiled by Hameed et al.57. Among these, we analyzed the 5 head-on and 10 co-directional core genes. Significance was determined by Student’s t test. p = 0.2 for HO vs. CD average dN/dS values