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. 2018 Nov 7;8:16499. doi: 10.1038/s41598-018-34738-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Congenital anomalies in channel catfish (Ictalurus punctatus) 4-month-old fingerlings microinjected at the one cell stage with gRNAs/Cas9 protein targeting toll/interleukin 1 receptor domain-containing adapter molecule (TICAM 1) gene and rhamnose binding lectin (RBL) gene. (A) Absence of the right barbels. (B) Absence of the left eye. (C) Spinal deformity. (D) The head is curved to the left side with mouth deformity. (E,F) Normal fish. All injected and non-injected 4-month-old control fry were free of any anomalies. Photos by Ahmed Elaswad.