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. 2018 Nov 7;8:16506. doi: 10.1038/s41598-018-34873-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MAIT cell subsets in LCH. (a) Gating strategy for identifying CD8 and CD4 cells in MAIT cells from the peripheral blood from healthy donors (top left) and LCH patients (PB) (top right), and in lesional MAIT cells from patients with LCH (bottom left). (b) Proportions of CD4⁺, CD8⁺, and CD8⁻CD4⁻ cells in MAIT cells from the peripheral blood from healthy donors (HD), patients with non-active LCH (PB-NAD) and active LCH (PB-AD) and in lesional MAIT cells from patients with active LCH. Kruskal-Wallis tests with Dunn’s multiple comparisons were conducted for (b) except where only two groups were compared (Mann Whitney test), error bars indicate median + interquartile range, 10⁻³ on logarithmic scale indicates ‘undetectable’.