Figure 4.

Expression of Jagged1, Notch1-ICD, Hes5, and p-STAT3 and the correlations among the Sham, RK, RK + OA, RK + OA + Tea, and RK + OA + Tea + AP groups. A: mRNA levels were detected by qPCR. The levels of Jagged1, Notch1-ICD, and Hes5 were remarkably decreased in the RK rats and RK rats treated with OA. The administration of Tea or AP reversed the effect of OA. B: Protein levels were measured by western blot methods. Jagged1, Notch1-ICD, Hes5, and p-STAT3 expression was reduced in the RK rats and RK rats treated with OA. The administration of Tea or AP reversed the effect of OA. C: Correlations between the levels of Jagged1, Notch1-ICD, Hes5, and p-STAT3, A Pearson’s correlation analysis showed positive correlations among the levels of Notch1-ICD, Jagged1, Notch1-ICD, Hes5, p-STAT3, and MnSOD2.