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The mechanism by which TM contributes to eotaxin-2-mediated apoptosis in monocytic cells. TM may regulate cell apoptosis via the PI3K/Akt axis signaling pathway, which acts as an extinguisher for p53 and BAX activation, as well as further downstream cytochrome c release and caspase 8 and 3 cleavage. The interaction between TM and cofilin further supported a role for TM in cell apoptosis.
