Table 1.
Descriptive data of included adults in the study
| Parameter | Lung cancer (N = 41) | Healthy controls (n = 41) | P-Value |
|---|---|---|---|
| Age (years; mean ± SD) (range)* | 57.97 (7.68) (41-71) | 59.05 (6.78) (48-74) | 0.50 |
| Females/Males, No. (%)# | 11/30 (26.83%/73.17%) | 15/26 (36.59%/63.41%) | 0.48 |
| BMI (mean, SD) (range)* | 24.05 (1.91) (20.08-27.16) | 23.38 (2.09) (19.13-28.08) | 0.13 |
| Smoking status (%)# | 0.12 | ||
| Never smoker | 15 (36.59%) | 23 (56.10%) | |
| Ever smoker | 26 (63.41%) | 18 (43.90%) | |
| Alcohol consumption status (%)# | 0.89 | ||
| Never drinker | 25 (60.98%) | 23 (56.10%) | |
| < 1 standard drink per day | 6 (14.63%) | 11 (26.83%) | |
| ≥ 1 standard drink per day | 10 (24.39%) | 7 (17.07%) | |
| Final diagnosis | NA | ||
| Non-small cell cancer | 34 (82.93%) | ||
| Adenocarcinoma | 22 (53.66%) | ||
| Squamous cell cancer | 12 (29.27%) | ||
| Stage I/II/III/IV | 11/12/18/0 (26.83%/29.27%/43.90%/0) | ||
| Small cell cancer | 7 (17.07%) | ||
| NLR, mean (SD) | 2.60 (1.25) | NA | |
| PNI, mean (SD) | 49.43 (5.04) | NA | |
| PLR, mean (SD) | 146.15 (53.58) | NA | |
| PLT, mean (SD) | 241.17 (80.07) | NA | |
| IL-6 (pg/ml), mean (SD)* | 5.75 (4.23) | 3.90 (2.53) | 0.020 |
| IL-12 (pg/ml), mean (SD)* | 20.39 (6.58) | 23.08 (7.54) | 0.089 |
| IL-17 (pg/ml), mean (SD)* | 33.72 (1.63) | 25.20 (1.19) | 0.008 |
| sCTLA-4 (ng/ml), mean (SD)* | 9.53 (6.25) | 21.51 (2.78) | 0.009 |
*
Student’s t test;
#
Chi-square test;
Abbreviations: BMI, body mass index; NLR, neutrophil-lymphocyte ratio; PNI, prognostic nutritional index; PLR, platelet-lymphocyte ratio; PLT, platelet; IL-6, interleukin-6; IL-12, interleukin-12; IL-17, interleukin-17; s-CTLA-4, soluble cytotoxic T lymphocyte associated antigen-4; NA, not available.