Skip to main content
. 2018 Oct 15;10(10):3086–3098.

Figure 1.

Figure 1

Metformin enhances the inhibitory effect of cisplatin on proliferation in vitro. A-D. SKOV3 and Hey cells were treated with metformin (0 mmol/L, 5 mmol/L, 10 mmol/L, 20 mmol/L, 40 mmol/L, 50 mmol/L) or cisplatin (0 µg/mL, 0.4 µg/mL, 0.8 µg/mL, 1.6 µg/mL, 3.2 µg/mL, 6.4 µg/mL) alone for 24, 48 and 72 hours. The CCK-8 assay was performed to detect cell viability. E, F. SKOV3 and Hey cells were treated with metformin (5 mmol/L) combined with cisplatin (0.4 µg/mL, 0.8 µg/mL, 1.6 µg/mL, 3.2 µg/mL) for 48 hours. The CCK-8 assay was used to detect cell viability. *, P<0.05, **, P<0.01, and ***, P<0.001.