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Combination therapy with metformin and cisplatin inhibited ovarian cancer proliferation and EMT in vivo through the TGFβ signalling pathway. Representative (×400) staining showing N-cadherin, MMP-9, Ki-67, cleaved caspase-3, P-Smad2 and P-Smad3 expression in tumour tissues excised from mice at 3 weeks. *, P<0.05 and ***, P<0.001.
