Table 3.

Correlation among immunological expression and clinicopathological factors

	N	PD-L1 expression			CD8 expression			CD4 expression			Foxp3 expression
		Negative (N = 25)	Positive (N = 70)	p-valuea	Negative (N = 52)	Positive (N = 43)	p-valuea	Negative (N = 19)	Positive (N = 76)	p-valuea	Negative (N = 52)	Positive (N = 43)	p-valuea
Age
< 74	46	11	35	0.61	27	19	0.45	12	34	0.15	26	20	0.74
≥ 74	49	14	35		25	24		7	42		26	23
Gender
Male	82	19	63	0.08	43	39	0.26	14	68	0.07	44	38	0.60
Female	13	6	7		9	4		5	8		8	5
Smoking history
Yes	91	23	68	0.27	50	41	0.85	18	73	0.80	50	41	0.85
No	4	2	2		2	2		1	3		2	2
Stage
I	54	14	40	0.60	29	25	0.82	8	46	0.15	27	27	0.29
II-IV	41	11	40		23	18		11	30		25	16
Lymphatic permeation
No	31	4	27	0.04b	17	14	0.88	3	28	0.10	15	16	0.46
Yes	62	20	42		33	29		15	47		35	27
Vascular invasion
No	25	6	19	0.89	17	8	0.08	4	21	0.60	17	8	0.11
Yes	67	17	50		32	35		14	53		33	34
Pleural invasion
No	57	13	44	0.45	33	24	0.38	9	48	0.30	29	28	0.42
Yes	37	11	26		18	19		9	28		22	15
CD8 expression
Negative	52	16	36	0.28	-	-		-	-		-	-
Positive	43	9	34		-	-		-	-		-	-
CD4 expression
Negative	19	7	12	< 0.01b	6	1	< 0.01b	-	-		-	-
Positive	76	18	58		0	42		-	-		-	-
Foxp3 expression
Negative	52	18	34	0.04b	39	13	< 0.01b	17	35	< 0.01b	-	-
Positive	43	7	36		13	30		2	41		-	-

^aPeason’s chi-square test;

^bdenotes significance.