Table 4.
Univariate and Multivariate analyses
OS | RFS | |||||||
---|---|---|---|---|---|---|---|---|
| ||||||||
Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
| ||||||||
N = 95 | p-valuea | HR | p-valueb | N = 92 | p-valuea | HR | p-valueb | |
Age | ||||||||
≥ 74/< 74 | 49/46 | 0.12 | 48/44 | 0.13 | ||||
Gender | ||||||||
Male/Female | 82/13 | 0.32 | 79/13 | 0.22 | ||||
Smoking history | ||||||||
Yes/No | 4/91 | 0.50 | 3/89 | 0.81 | ||||
Stage | ||||||||
II-IV/I | 41/54 | 0.13 | 38/54 | 0.02c | 1.97 (1.05-3.71) | 0.03c | ||
Lymphatic permeation | ||||||||
Yes/No | 62/31 | 0.10 | 29/61 | < 0.01c | 1.93 (0.94-3.97) | 0.07 | ||
Vascular invasion | ||||||||
Yes/No | 67/25 | 0.72 | 66/23 | 0.09 | ||||
Pleural invasion | ||||||||
Yes/No | 37/57 | 0.02c | 2.82 (1.21-3.93) | < 0.01c | 35/56 | < 0.01c | 2.23 (1.23-4.04) | < 0.01c |
Adjuvant therapy | ||||||||
No/Yes | 72/23 | 0.08 | 70/22 | 0.71 | ||||
PD-L1 expression | ||||||||
Negative/Positive | 25/70 | 0.25 | 25/67 | 0.09 | ||||
CD8 expression in whole tumor | ||||||||
Negative/Positive | 52/43 | 0.53 | 50/42 | 0.95 | ||||
CD8 expression in cancer nest | ||||||||
Negative/Positive | 71/24 | 0.67 | 69/23 | 0.61 | ||||
CD8 expression in cancer stroma | ||||||||
Negative/Positive | 45/50 | 0.44 | 43/49 | 0.82 | ||||
CD4 expression in whole tumor | ||||||||
Negative/Positive | 19/76 | 0.43 | 19/73 | 0.38 | ||||
CD4 expression in cancer nest | ||||||||
Negative/Positive | 80/15 | 0.69 | 77/15 | 0.68 | ||||
CD4 expression in cancer stroma | ||||||||
Negative/Positive | 17/78 | 0.14 | 17/75 | 0.03c | 0.31 (0.11-0.82) | 0.02c | ||
Foxp3 expression | ||||||||
Negative/Positive | 52/43 | 0.01c | 1.97 (1.06-3.68) | 0.03c | 50/42 | < 0.01c | 1.97 (1.05-3.71) | 0.04c |
Log-rank test;
Cox proportional hazard model;
denotes significance.