Figure 8.

HMGA2 silencing or inhibition of the ATR/Chk1 signaling pathway inhibited lymph node metastasis in xenografts of nude mice. Notes: (A) Based on HE staining (A, 400 ×) and the number of positive lymph nodes (B) indicated that lymph node metastasis in xenografts of nude mice was reduced in response to caffeine transfection and increased in response to BCNU; *, P<0.05 vs. the blank group; the data of positive lymph nodes were were measurement data, expressed by mean ± standard deviation; the data of different groups were analyzed by one-way ANOVA; the experiment was repeated 3 times.