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. 2018 Nov 7;8:16509. doi: 10.1038/s41598-018-34735-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PIZV immunogenicity and efficacy in AG129 mice. (a) Test groups and schedule of dosing. (b) Serum NAb titers as determined by R-mFRNT of immunized AG129 mice. Solid lines represent the group GMT of the reciprocal serum dilution required for at least 50% reduction of viral foci. The limit of detection (1.3 log₁₀) is represented by a dashed line. Animals with no detectable titer (<1.3) were assigned a titer of 1.0 for visualization and GMT calculation. Data were analyzed by one-way ANOVA with Tukey’s multiple comparisons test: ****indicates p < 0.0001. (c) Infectious virus titers of individual mouse serum samples two days post-challenge, shown as pfu/mL. Solid lines represent the GMT of a group. Error bars represent standard deviation. The limit of detection (2.0 log₁₀) is represented by a dashed line. Animals with no detectable titer (<2.0) were assigned a titer of 1.0 for visualization and GMT calculation. (d) Kaplan-Meier survival curve of test groups post-challenge.