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. 2018 Nov 7;8:16475. doi: 10.1038/s41598-018-34830-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of intra-articular administration of BMS-345541 in early phase of OA. (a) Safranin O staining and immunohistochemistry of NF-κB-related proteins and catabolic enzymes in the BMS-345541-treated cartilage at 2 weeks after surgical induction of OA. Inset boxes in safranin O staining indicate enlarged images. Scale bar, 50 µm. (b) The percentage of positive cells in the immunohistochemistry. *P < 0.05 vs vehicle by the Kruskal-Wallis test & Dunn’s post hoc test for unequal variance, n = 4 mice per group.