Figure 3. Rapamycin improves mitochondrial ultrastructure in Cox15 ^sm/sm mice.

Note the accumulation of profoundly altered mitochondria in Cox15 ^sm/sm muscles (white arrows), possibly as a result of partially digested organelles within endolysosomes. Black arrows indicate examples of normal mitochondria. In rapamycin‐treated Cox15 ^sm/sm animals, only a few of these structures are present, which can be detected also in rapamycin‐treated WT samples. The scale bar corresponds to 1,136 nm (4,400×).