Table 2.

Summary of acrolein exposure and pharmacological blockade of autonomic function on ventilatory parameters in WT and TRPA1 KO mice; compared with FA-exposed controls

WT:	Treatment	Ti	Te	PIF	PEF	TV	RT	MV	Freq	PenH
Saline + Acrolein		NE	↑	NE	↑	↑	NE	NE	↓	↑
Atenolol + Acrolein		NE	NE	NE	↑	NE	↓	NE	NE	↑
Atropine + Acrolein		NE	↑	NE	↑	↑	↓	NE	NE	↑
Hexametdonium + Acrolein		↑ early	↑ early	↑	↑	↑↑	↑ early	↑	↓↑	↑

KO:	Treatment	Ti	Te	PIF	PEF	TV	RT	MV	Freq	PenH
Saline + Acrolein		NE	NE	NE	NE	NE	NE	NE	NE	↑at 180min
Atenolol + Acrolein		NE	NE	NE	NE	NE	NE	NE	NE	↑at 180min
Atropine + Acrolein		NE	NE	NE	NE	NE	NE	NE	NE	NE
Hexametdonium + Acrolein		NE	NE	NE	NE	NE	NE	NE	NE	↑at 180min

Ti = inspiratory time; Te = expiratory time; PIF = peak inspiratory time; PEF = peak expiratory time; TV = tidal volume; RT = relaxation time; MV = minute ventilation; Freq. = breatding frequency; PenH = enhanced pause.