Table 1.

Sensitivity and Specificity for Concurrent Cryptococcal Meningitis by Blood Cryptococcal Antigen Titer Cutoff Level in Patients With No Symptoms or Signs of Meningitis or With Headache Only (n = 62)^a

Blood CrAg Titer Cutoff	Sensitivity (95% CI), %	Specificity (95% CI), %
>5	100 (89.7–100)	21.4 (8.3–41.0)
>10	100 (89.7–100)	32.1 (15.8–52.4)
>20	100 (89.7–100)	46.4 (27.5–66.1)
>40	97.1 (84.7–99.9)	57.1 (37.2–75.5)
>80	91.2 (76.3–98.1)	71.4 (51.3–86.8)
>160	88.2 (72.5–96.7)	82.1 (63.1–93.9)
>320	79.4 (62.1–91.3)	85.7 (67.3–96.0)
>640	76.5 (58.8–89.3)	89.2 (71.8–97.7)
>1280	70.6 (52.5–84.9)	96.4 (81.7–99.9)
>2560	61.8 (43.6–77.8)	100 (87.7–100)

Abbreviations: CI, confidence interval; CrAg, cryptococcal antigen.

^aCrAg titers were determined using the serial dilution method.