Table 1. Metabolite Analysis of [11C]1 in Plasma, Brain, and Spinal Cord Supernatant.
| plasma |
brain |
spinal cord | |||||
|---|---|---|---|---|---|---|---|
| 5 min [%; SD] | 15 min [%; SD] | 45 min [%; SD] | 5 min [%; SD] | 15 min [%; SD] | 45 min [%; SD] | 15 min [%] | |
| intact tracer | 52.3 ± 11.3 | 15.2 ± 7.9 | 10.9 ± 3.0 | >99.9 | 97.3 ± 0.6 | 96.7 ± 4.5 | 97.6 |
| nonpolar metabolite 1 | 7.8 ± 5.4 | 7.9 ± 2.4 | 7.7 ± 2.9 | 0.9 ± 0.6 | 1.6 ± 3.2 | ||
| nonpolar metabolite 2 | 1.1 ± 1.1 | ||||||
| nonpolar metabolite 3 | 34.3 ± 5.0 | 40.8 ± 4.4 | 40.0 ± 1.7 | 1.8 ± 0.2 | 1.6 ± 3.2 | 2.4 | |
| polar metabolites | 5.2 ± 1.1 | 6.1 ± 0.4 | 5.7 ± 0.3 | ||||