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. 2018 Oct 31;9:2596. doi: 10.3389/fmicb.2018.02596

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Copyright © 2018 Barbezange, Jones, Blanc, Isakov, Celniker, Enouf, Shomron, Vignuzzi and van der Werf.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Distribution of vSNPs along the genome. A viral Single Nucleotide Polymorphism (vSNP) is a position with a significant variant that has been identified in at least 15% of the samples in a group. X-axis: nucleotide position along each genomic segment; Y-axis: percentage of samples sharing a significant variant. (A) sH3N2 samples. In purple: season 2008–2009; in blue: season 2011–2012. (B) pH1N1 samples. In green: season 2009–2010; in orange: season 2010–2011.