Table 1.
Baseline clinical characteristics in non-PSCI and PSCI patients at 1 month
| Non-PSCI (n=222) | PSCI (n=105) | P-value | |
|---|---|---|---|
| Demographic characteristics | |||
| Age (years), mean ± SD | 61.14±9.97 | 65.39±10.08 | <0.001 |
| Male/female | 153/69 | 54/51 | 0.003 |
| Married status, n (%) | 202 (91.0) | 90 (85.7) | 0.180 |
| Education levels, n (%) | 0.029 | ||
| Illiterate | 55 (24.8) | 41 (39) | |
| Primary school | 103 (46.4) | 38 (36.2) | |
| Postsecondary school | 64 (28.8) | 26 (24.8) | |
| TOAST classification, n (%) | 0.741 | ||
| LA | 180 (81.1) | 84 (80) | |
| CE | 12 (5.4) | 6 (5.7) | |
| SA | 23 (10.8) | 11 (10.5) | |
| SOE | 4 (1.8) | 1 (1.0) | |
| SUE | 2 (0.9) | 3 (2.9) | |
| Lesion location, n (%) | 0.840 | ||
| Left hemisphere | 69 (31.1) | 37 (35.2) | |
| Right hemisphere | 79 (35.6) | 31 (29.5) | |
| Brainstem | 36 (16.2) | 18 (17.1) | |
| Cerebellum | 10 (4.5) | 4 (3.8) | |
| Others | 28 (12.6) | 15 (14.3) | |
| Multiple infarcts, n (%) | 85 (38.3) | 52 (49.5) | 0.056 |
| Vascular risk factors, n (%) | |||
| Hypertension | 157 (70.7) | 73 (69.5) | 0.897 |
| Diabetes mellitus | 63 (28.4) | 37 (35.2) | 0.247 |
| Hyperlipidemia | 21 (9.5) | 10 (9.5) | 1.000 |
| Coronary artery disease | 14 (6.3) | 8 (7.6) | 0.814 |
| History of stroke | 17 (7.7) | 12 (11.4) | 0.299 |
| Current smoking | 73 (32.9) | 20 (19.0) | 0.012 |
| Current drinking | 89 (40.1) | 38 (36.2) | 0.544 |
| NIHSS score, median (IQR) | 2.5 (1–4) | 3 (1.5–5) | 0.210 |
| HAMA score, median (IQR) | 4 (1–7) | 4 (1–8) | 0.800 |
| HAMD score, median (IQR) | 4 (2–7) | 5 (1–9) | 0.616 |
| Poor outcome, n (%) | 31 (14.2) | 22 (21.0) | 0.148 |
| BI score, median (IQR) | 100 (98–100) | 100 (91–100) | |
| Laboratory data | |||
| Mg2+ (mmol/L), mean ± SD | 0.86±0.07 | 0.83±0.09 | 0.003 |
| HbA1c (mmol/L), mean ± SD | 6.36±1.59 | 6.28±1.26 | 0.707 |
| FBG (mmol/L), mean ± SD | 5 (4.4–5.9) | 4 (4.6–6.4) | 0.257 |
| PBG (mmol/L), mean ± SD | 7.6 (6.0–10.6) | 8.1 (6.0–12.4) | 0.391 |
Abbreviations: BI, Barthel Index; CE, cardioembolism; FBG, fasting blood glucose; HAMA, Hamilton Anxiety Rating Scale; HAMD, Hamilton Depression Rating Scale; HbA1c, hemoglobin A1c; LA, large-artery atherosclerosis; Mg2+, magnesium; MMSE, Mini–Mental State Examination; NIHSS, National Institutes of Health Stroke Scale; PBG, postprandial blood glucose; PSCI, poststroke cognitive impairment; SA, small-artery occlusion lacunar; SOE, stroke of other determined etiology; SUE, stroke of other undetermined etiology; TOAST, Trial of Org 10172 in Acute Stroke Treatment.