Table 3.

Factors associated with overall survival of patients with HCC in the absence of cirrhosis

Variables	Univariate analysis			Multivariate analysis
	HR	95%CI	P values	HR	95%CI	P values
Age > 50 yrs	1.01	0.99–1.03	0.283
Gender (male)	0.85	0.51–1.40	0.517
Family history of HCC	1.16	0.51–2.67	0.72
Alcohol abuse	1.76	1.18–2.63	0.006
Diabetes	1.41	0.83–2.38	0.202
Hypertension	0.85	0.53–1.36	0.507
Hyperlipidemia	0.98	0.54–1.80	0.949
Etiology
HBV	0.62	0.39–0.97	0.037
HCV	1.8	1.08–3.02	0.025
Alcohol abuse	1.54	0.71–3.32	0.272
NAFLD	2.07	0.65–6.54	0.216
HBV-DNA ≥ 500 IU/ml	1.36	0.88–2.10	0.164
Antiviral therapy	0.52	0.32–0.86	0.011	0.53	0.32–0.89	0.015
PVTT at baseline	6.17	3.32–11.46	< 0.0001	3.4	1.73–6.67	< 0.0001
Leukocyte counts	1.05	0.96–1.14	0.332
NLR	0.99	0.95–1.03	0.675
Platelets (109/L)	1.002	0.999–1.005	0.193
AST (U/L)	1.002	0.998–1.006	0.403
Totall Bilirubin (umol/L)	1.005	1.002–1.008	0.001
Albumin (g/L)	0.939	0.902–0.978	0.002
γ-GGT (U/L)	1.006	1.004–1.008	< 0.0001	1.006	1.004–1.009	< 0.0001
Triglyceride (mmol/L)	0.7	0.44–1.11	0.128	0.51	0.29–0.89	0.017
PTA (%)	0.986	0.973–0.999	0.032
AFP ≥ 400 ng/ml	2.235	1.469–3.40	< 0.0001
Tumor size > 5 cm	3.99	2.65–6.02	< 0.0001	2.79	1.72–4.50	< 0.0001
Tumor numbers ≥2	2.3	1.53–3.46	< 0.0001
CRP (mg/L)	1.008	1.003–1.013	0.002

Abbreviations: CRP C-reactive protein