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. 2018 Nov 6;15:307. doi: 10.1186/s12974-018-1347-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Microglial response increased but saturated relative to ongoing amyloidosis during aging. Plots show cortical Standardized Uptake Value Ratio (SUVR) of [¹⁸F]-GE180 (TSPO-activity) (a) and [¹⁸F]-florbetaben (amyloidosis) (b) in APP-SL70 mice at different ages (B) APP-SL70 indicate increasing cortical amyloidosis and 18 kDa translocator protein (TSPO) binding during aging (c). Percentage change for both PET tracers between baseline and + 6.3 months as a function of baseline age in APP-SL70 mice and wt reveal an inverted U-shape for TSPO activity (quadratic fit, R = 0.69, p = 0.014 (d) but a linear positive association for amyloidosis in APP-SL70 (linear fit, R = 0.50, p = 0.048 (e). N = 17