Table 1.

Interventions received according to the 2 × 2 factorial trial design. Randomisation is 1:1 between the two topical cream arms and 1:1 for qHPV and placebo

		Topical creams
		Imiquimod	Podophyllotoxin
Vaccines	qHPV vaccine	Arm A n = 125 Imiquimod cream for 16 weeks; qHPV vaccine at months 0, 2 and 6	Arm B n = 125 Podophyllotoxin cream for 4 weeks; qHPV vaccine at months 0, 2 and 6
	Saline, placebo control	Arm C n = 125 Imiquimod cream for 16 weeks; placebo vaccine at months 0, 2 and 6	Arm D n = 125 Podophyllotoxin cream for 4 weeks; placebo vaccine at months 0, 2 and 6.