Table 3.

Association of haemoglobin with global and regional cortical thickness

Hb (per g/dl decrease)	Global cortical thickness (mm), β (95% CI)a	Region-specific cortical thickness
		Frontal (mm) β (95% CI)*	Insula (mm) β (95% CI)*	Occipital (mm) β (95% CI)*	Temporal (mm) β (95% CI)*	Limbic (mm) β (95% CI)*	Parietal (mm) β (95% CI)*
Model I	− 0.009 (− 0.014, − 0.003)	−0.006 (− 0.012, − 0.001)	−0.007 (− 0.015, 0.001)	−0.015 (− 0.022, − 0.008)	−0.009 (− 0.016, − 0.002)	−0.007 (− 0.013, − 0.001)	−0.009 (− 0.016, − 0.002)
	p = 0.002	p = 0.032	p = 0.105	p < 0.001	p = 0.014	p = 0.015	p = 0.010
Model II	−0.006 (− 0.013, − 0.001)	−0.005 (− 0.011, 0.002)	−0.004 (− 0.013, 0.005)	−0.012 (− 0.020, − 0.005)	−0.007 (− 0.014, 0.000)	−0.006 (− 0.012, 0.001)	−0.005 (− 0.013, 0.002)
	p = 0.025	p = 0.149	p = 0.426	p = 0.001	p = 0.066	p = 0.076	p = 0.185
Model III	− 0.005 (− 0.011, 0.001)	− 0.003 (− 0.009, 0.003)	−0.001 (− 0.010, 0.008)	−0.011(− 0.019, − 0.004)	−0.005 (− 0.012, 0.003)	−0.004 (− 0.020, 0.012)	− 0.004 (− 0.011, 0.004)
	p = 0.091	p = 0.299	p = 0.814	p = 0.003b	p = 0.219	p = 0.185	p = 0.320

Hb haemoglobin

Model I: adjusted for age, gender, race and smoking status

Model II: Model I + hypertension, hyperlipidaemia, diabetes mellitus, glomerular filtration rate and BMI

Model III: Model II + magnetic resonance imaging markers (intracranial volume, lacunes, white matter hyperintensities, cerebral microbleeds, cortical cerebral microinfarcts)

^aThe reported confidence interval and p values are for decreased haemoglobin levels. These values are extracted from the multivariable models which also included covariates

^bSignificant after Bonferroni correction: p = 0.0083