Table 4.
Association of haemoglobin with subcortical structure volumes
| Hb (per g/dl decrease) | Accumbens (ml), β (95% CI)a |
Amygdala (ml), β (95% CI)a |
Caudate (ml), β (95% CI)a |
Pallidum (ml), β (95% CI)a |
Putamen (ml), β (95% CI)a |
Thalamus (ml), β (95% CI)a |
Hippocampus (ml), β (95% CI)a |
Brainstem (ml), β (95% CI)a |
|---|---|---|---|---|---|---|---|---|
| Model I | − 0.02 (− 0.03, − 0.01) | −0.02 (− 0.04, 0.00) | −0.03 (− 0.08, 0.02) | −0.01 (− 0.04, 0.01) | −0.08 (− 0.14, − 0.01) | −0.03 (− 0.09, 0.02) | −0.04 (− 0.08, 0.01) | −0.15 (− 0.27, − 0.03) |
| p < 0.001 | p = 0.055 | p = 0.291 | p = 0.233 | p = 0.019 | p = 0.245 | p = 0.097 | p = 0.014 | |
| Model II | −0.02 (− 0.03, − 0.01) | −0.02 (− 0.04, 0.01) | 0.00 (− 0.06, 0.05) | 0.00 (− 0.03, 0.02) | −0.05 (− 0.11, 0.02) | −0.01 (− 0.06, 0.07) | −0.02 (− 0.07, 0.02) | −0.07 (− 0.20, 0.06) |
| p = 0.001 | p = 0.134 | p = 0.899 | p = 0.833 | p = 0.190 | p = 0.870 | p = 0.366 | p = 0.312 | |
| Model III | −0.01 (−0.02, 0.00) | −0.01 (− 0.04, 0.01) | −0.02 (− 0.07, 0.03) | 0.00 (− 0.02, 0.02) | −0.05 (− 0.12, 0.02) | 0.01 (− 0.04, 0.07) | −0.02 (− 0.06, 0.03) | −/0.04 (− 0.16, 0.08) |
| p = 0.005b | p = 0.215 | p = 0.493 | p = 0.912 | p = 0.169 | p = 0.629 | p = 0.433 | p = 0.551 |
Hb Haemoglobin
Model I: adjusted for age, gender, race and smoking status
Model II: Model I + hypertension, hyperlipidaemia, diabetes mellitus, glomerular filtration rate and body mass index
Model III: Model II + magnetic resonance imaging markers (intracranial volume, lacunes, white matter hyperintensities, cerebral microbleeds, cortical cerebral microinfarcts)
aThe reported confidence interval and p values are for decreased haemoglobin levels. These values are extracted from the multivariable models which also included covariates
bSignificant after Bonferroni correction p = 0.00625