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. 2018 Jun 10;7(12):e008441. doi: 10.1161/JAHA.117.008441

Figure 5.

Figure 5

Advanced cardiac fibrosis in insulin‐like peptide 6–knockout (KO) mice in the isoproterenol (Iso) model compared with wild‐type (WT) mice. A, Heart sections stained by Picrosirius Red staining. Representative images of interstitial left ventricular fibrosis of endocardium are shown. B, Cardiac fibrosis area was quantified as pixel count. C, Relative transcript level of Tgfb1, Col1a1, and Col3a1 in hearts assessed by real‐time quantitative polymerase chain reaction. Error bars represent mean±SD (n=8, 6, 12, and 10 for WT‐sham, KO‐sham, WT‐Iso, and KO‐Iso, respectively). *P<0.05, **P<0.005 indicate significant differences between sham and isoproterenol group in the same mouse strain. # P<0.05, ## P<0.005 indicate significant differences between WT and KO.