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. 2018 Jun 10;7(12):e008441. doi: 10.1161/JAHA.117.008441

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© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Recombinant insulin‐like peptide 6 (INSL6) protein attenuated isoproterenol (Iso)–induced cardiac fibrosis in wild‐type (WT) mice. A, Representative Picrosirius Red staining images for hearts from C57BL6/N mice injected with 10 days of Iso with continuous vehicle or INSL6 protein administration. Whole heart (top) and zoomed‐in left ventricle (LV; bottom) images were shown. B, Cardiac fibrosis area was quantified by pixel count from zoomed‐in LV images. C, Relative transcript level of Tgfb1, Col1a1, and Col3a1 in hearts assessed by real‐time quantitative polymerase chain reaction. Error bars represent mean±SD (n=9 for Iso+vehicle, n=8 for Iso+INSL6). KO indicates knockout. *P<0.05 indicates significant differences found between 2 groups.