Table 2.
Physiological Findings of WT and Insl6‐Knockout Mice Induced With or Without AngII
| Variable | Sham | AngII | ||||
|---|---|---|---|---|---|---|
| WT (n=12) | Knockout (n=12) | P Value Sham Groupa | WT (n=16) | Knockout (n=16) | P Value AngII Groupa | |
| BW, g | 27.44±2.09 | 27.65±2.40 | 0.9642 | 24.48±2.01 | 24.43±1.97 | 0.9976 |
| HW/TL, mg/mmb | 5.87±0.59 | 5.69±0.55 | 0.8972 | 7.50±1.32 | 8.42±1.40 | 0.0430 |
| HW/BW, mg/gb | 4.91±0.51 | 4.71±0.41 | 0.8040 | 6.87±0.93 | 7.903±1.10 | 0.0019 |
| LW/TL, mg/mmc | 7.14±1.42 | 6.81±1.45 | 0.8773 | 6.89±1.73 | 8.40±2.30 | 0.0430 |
| LW/BW, mg/gc | 5.94±1.00 | 5.61±0.99 | 0.8253 | 6.40±1.38 | 7.80±2.06 | 0.0190 |
| Systolic BP, mm Hg | 106.4±5.21 | 109.3±8.72 | 0.9746 | 156.3±10.41 | 156.2±11.64 | >0.999 |
Data are shown as mean±SD. AngII indicates angiotensin II; BP, blood pressure; BW, body weight; HW, heart weight; Insl6, insulin‐like peptide 6; LW, lung weight; TL, tibia length; WT, wild type.
a
Ordinary 2‐way ANOVA, Sidak's multiple comparison test between WT and knockout in the same experimental group.
b
HW is normalized by TL (HW/TL) or BW (HW/BW).
c
LW is normalized by TL (LW/TL) or BW (LW/BW).