Table 2.
Associations of Baseline Serum Non–HDL‐C With All‐Cause and Cardiovascular Mortality
| Non‐HDL‐C, mg/dL | Unadjusted | Case Mix | Case Mix and MICS | Case Mix, MICS, and Statin | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P Value | HR | 95% CI | P Value | HR | 95% CI | P Value | HR | 95% CI | P Value | |
| All‐cause mortality | ||||||||||||
| <60 | 1.98 | 1.70–1.96 | <0.001 | 1.73 | 1.61–1.87 | <0.001 | 1.63 | 1.49–1.79 | <0.001 | 1.64 | 1.48–1.82 | <0.001 |
| 60–<85 | 1.42 | 1.36–1.58 | <0.001 | 1.33 | 1.25–1.41 | <0.001 | 1.31 | 1.22–1.40 | <0.001 | 1.32 | 1.23–1.42 | <0.001 |
| 85–<100 | 1.11 | 1.25–1.45 | 0.001 | 1.06 | 1.00–1.13 | 0.050 | 1.07 | 1.01–1.14 | 0.035 | 1.09 | 1.01–1.17 | 0.022 |
| 100–<115 | 1.00 | … | … | 1.00 | … | … | 1.00 | … | … | 1.00 | … | … |
| 115– <130 | 0.96 | 0.94–1.10 | 0.292 | 1.01 | 0.94–1.08 | 0.881 | 0.99 | 0.92–1.05 | 0.704 | 1.01 | 0.94–1.09 | 0.794 |
| 130–<145 | 0.87 | 0.81–0.96 | 0.001 | 0.96 | 0.88–1.03 | 0.255 | 0.93 | 0.85–1.01 | 0.093 | 0.95 | 0.86–1.04 | 0.257 |
| 145–<160 | 0.90 | 0.84–0.99 | 0.013 | 1.01 | 0.92–1.10 | 0.874 | 0.95 | 0.86–1.06 | 0.360 | 0.99 | 0.89–1.11 | 0.890 |
| ≥160 | 0.86 | 0.81–0.95 | <0.001 | 1.01 | 0.94–1.09 | 0.700 | 0.89 | 0.80–1.00 | 0.049 | 0.98 | 0.86–1.10 | 0.698 |
| Cardiovascular mortality | ||||||||||||
| <60 | 2.06 | 1.82–2.33 | <0.001 | 1.75 | 1.54–1.99 | <0.001 | 1.65 | 1.41–1.93 | <0.001 | 1.73 | 1.46–2.06 | <0.001 |
| 60–<85 | 1.52 | 1.38–1.68 | <0.001 | 1.40 | 1.27–1.54 | <0.001 | 1.37 | 1.22–1.53 | <0.001 | 1.41 | 1.25–1.60 | <0.001 |
| 85–<100 | 1.18 | 1.06–1.31 | 0.002 | 1.12 | 1.01–1.25 | 0.029 | 1.13 | 1.01–1.26 | 0.030 | 1.16 | 1.03–1.31 | 0.013 |
| 100–<115 | 1.00 | … | … | 1.00 | … | … | 1.00 | … | … | 1.00 | … | … |
| 115–<130 | 0.93 | 0.83–1.05 | 0.224 | 0.96 | 0.86–1.08 | 0.538 | 0.95 | 0.84–1.08 | 0.440 | 0.97 | 0.85–1.11 | 0.670 |
| 130–<145 | 0.91 | 0.80–1.04 | 0.179 | 1.00 | 0.88–1.14 | 0.986 | 0.98 | 0.85–1.13 | 0.804 | 1.01 | 0.87–1.18 | 0.882 |
| 145–<160 | 0.91 | 0.79–1.06 | 0.229 | 1.03 | 0.89–1.20 | 0.673 | 1.00 | 0.84–1.18 | 0.996 | 1.09 | 0.91–1.31 | 0.326 |
| ≥160 | 0.88 | 0.78–1.00 | 0.048 | 1.03 | 0.91–1.17 | 0.607 | 0.97 | 0.80–1.17 | 0.728 | 1.06 | 0.86–1.29 | 0.587 |
Adjustments in case‐mix model: age, sex, race/ethnicity, primary insurance, vascular access type, comorbid conditions, and single‐pool Kt/V; case‐mix plus MICS models: case‐mix–adjusted model plus body mass index and laboratory parameters, including serum hemoglobin, white blood cell count, albumin, calcium, phosphorus, intact parathyroid hormone, bicarbonate, total iron‐binding capacity, ferritin, and low‐density lipoprotein cholesterol; case‐mix plus MICS plus statin models: statin therapy in addition to all covariates in case‐mix and MICS models. CI indicates confidence interval; HDL‐C, high‐density lipoprotein cholesterol; HR, hazard ratio; MICS, malnutrition‐inflammation‐cachexia syndrome.